Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.

نویسندگان

  • Akiko Nagai
  • Naoaki Yokoyama
  • Tomohide Matsuo
  • Sabine Bork
  • Haruyuki Hirata
  • Xuenan Xuan
  • Yinchang Zhu
  • Florencia G Claveria
  • Kozo Fujisaki
  • Ikuo Igarashi
چکیده

Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 2  شماره 

صفحات  -

تاریخ انتشار 2003